The Entourage Effect: The Synergy of Cannabis

Updated: Jul 20

The entourage effect is the theory that various cannabis compounds, such as THC, CBD and many other natural chemicals, work together synergistically to create unique effects and benefits of cannabis use.

When we smoke or vaporize cannabis, our bodies take in hundreds of botanical compounds. Each compound arrives with unique effects and benefits; their behavior may change in the presence of other cannabis compounds.


A simple example of the entourage effect would be the combination of THC & CBD versus pure THC or CBD. In a 2010 study, patients with cancer pain were given either a pure THC extract or an extract containing near-equal levels of both THC and CBD - patients given the THC and CBD. The patients that were given the THC/CBD combo reported having less pain.


Cannabis is far more than just THC and CBD.